Format

Send to

Choose Destination
Front Neuroanat. 2014 Oct 13;8:114. doi: 10.3389/fnana.2014.00114. eCollection 2014.

Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson's and other brain diseases.

Author information

1
Department of Neurology, Columbia University Medical Center New York, NY, USA.
2
Department of Physiology and Cellular Biophysics, Columbia University Medical Center New York, NY, USA.
3
Department of Neurology, Columbia University Medical Center New York, NY, USA ; Departments of Psychiatry and Pharmacology, Columbia University Medical Center New York, NY, USA.

Abstract

Neuronal expression of major histocompatibility complex I (MHC-I) has been implicated in developmental synaptic plasticity and axonal regeneration in the central nervous system (CNS), but recent findings demonstrate that constitutive neuronal MHC-I can also be involved in neurodegenerative diseases by playing a neuroinflammtory role. Recent reports demonstrate its expression in vitro and in human postmortem samples and support a role in neurodegeneration involving proinflammatory cytokines, activated microglia and increased cytosolic oxidative stress. Major histocompatibility complex I may be important for both normal development and pathogenesis of some CNS diseases including Parkinson's.

KEYWORDS:

major histocompatibility complex class I; neurodegeneration; neuroinflammation; neurons; plasticity

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center