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Clin Infect Dis. 2014 Nov 15;59 Suppl 5:S335-9. doi: 10.1093/cid/ciu612.

Antibiotic-resistant gram-negative bacterial infections in patients with cancer.

Author information

1
Medical and Research Services, Louis Stokes Cleveland Veterans Affairs Medical Center Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio;
2
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston.

Abstract

Patients with cancer are at high risk for infections caused by antibiotic resistant gram-negative bacteria. In this review, we summarize trends among the major pathogens and clinical syndromes associated with antibiotic resistant gram-negative bacterial infection in patients with malignancy, with special attention to carbapenem and expanded-spectrum β-lactam resistance in Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia--all major threats to our cancer patients. Optimal therapy for these antibiotic-resistant pathogens still remains to be determined.

KEYWORDS:

Acinetobacter baumannii; Pseudomonas aeruginosa; carbapenem-resistant Enterobacteriaceae; infections; neutropenia

PMID:
25352627
PMCID:
PMC4303050
DOI:
10.1093/cid/ciu612
[Indexed for MEDLINE]
Free PMC Article

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