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Org Lett. 2014 Nov 7;16(21):5736-9. doi: 10.1021/ol5024882. Epub 2014 Oct 29.

A universal isocyanide for diverse heterocycle syntheses.

Author information

1
Department of Drug Design, University of Groningen , Groningen, The Netherlands.

Abstract

Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.

PMID:
25351886
PMCID:
PMC4227542
DOI:
10.1021/ol5024882
[Indexed for MEDLINE]
Free PMC Article

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