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J Org Chem. 2014 Nov 21;79(22):11277-84. doi: 10.1021/jo5021618. Epub 2014 Nov 12.

Copper-catalyzed C-H functionalization of pyridines and isoquinolines with vinyl azides: synthesis of imidazo heterocycles.

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1
Academy of Scientific & Innovative Research, CSIR-Central Salt & Marine Chemicals Research Institute , Gijubhai Badheka Marg, Bhavnagar-364 002, Gujarat, India.

Abstract

Copper(I) iodide-catalyzed oxidative C(sp(2))-H functionalization of pyridines and isoquinolines for the synthesis of imidazo[1,2-a]pyridines and 2-phenylimidazo[2,1-a]isoquinolines with vinyl azides under mild aerobic conditions is reported. Good selectivity for 3-substituted pyridines and single isomer formation with isoquinolines were observed.

PMID:
25350716
DOI:
10.1021/jo5021618

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