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PLoS One. 2014 Oct 28;9(10):e111007. doi: 10.1371/journal.pone.0111007. eCollection 2014.

The functional connectivity landscape of the human brain.

Author information

1
Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada.
2
Department of Radiology, University of Washington, Seattle, Washington, United States of America.
3
MIND Research Institute, Irvine, California, United States of America.
4
School of Nursing, University of Michigan, Ann Arbor, Michigan, United States of America.
5
Department of Psychology, University of Michigan, Ann Arbor, Michigan, United States of America.
6
Department of Psychology, Chungnam University, Daejeon, South Korea.
7
Department of Psychology, University of South Carolina, Columbia, South Carolina, United States of America.
8
Department of Psychology, University of South Carolina, Columbia, South Carolina, United States of America; Department of Psychology, University of Chicago, Chicago, Illinois, United States of America.

Abstract

Functional brain networks emerge and dissipate over a primarily static anatomical foundation. The dynamic basis of these networks is inter-regional communication involving local and distal regions. It is assumed that inter-regional distances play a pivotal role in modulating network dynamics. Using three different neuroimaging modalities, 6 datasets were evaluated to determine whether experimental manipulations asymmetrically affect functional relationships based on the distance between brain regions in human participants. Contrary to previous assumptions, here we show that short- and long-range connections are equally likely to strengthen or weaken in response to task demands. Additionally, connections between homotopic areas are the most stable and less likely to change compared to any other type of connection. Our results point to a functional connectivity landscape characterized by fluid transitions between local specialization and global integration. This ability to mediate functional properties irrespective of spatial distance may engender a diverse repertoire of cognitive processes when faced with a dynamic environment.

PMID:
25350370
PMCID:
PMC4211704
DOI:
10.1371/journal.pone.0111007
[Indexed for MEDLINE]
Free PMC Article

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