Format

Send to

Choose Destination
J Cell Biol. 2014 Oct 27;207(2):171-9. doi: 10.1083/jcb.201408039.

The cell biology of planar cell polarity.

Author information

1
Department of Molecular Biology, Princeton University, Princeton, NJ 08544 danelle@princeton.edu.

Abstract

Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP components and intercellular communication to coordinate polarity between neighboring cells. Recent progress has been made toward understanding how protein transport, endocytosis, and intercellular interactions contribute to asymmetric PCP protein localization. Additionally, the functions of gradients and mechanical forces as global cues that bias PCP orientation are beginning to be elucidated. Together, these findings are shedding light on how global cues integrate with local cell interactions to organize cellular polarity at the tissue level.

PMID:
25349257
PMCID:
PMC4210441
DOI:
10.1083/jcb.201408039
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center