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Europace. 2015 Feb;17(2):207-14. doi: 10.1093/europace/euu213. Epub 2014 Oct 27.

A cost-effectiveness analysis of screening for silent atrial fibrillation after ischaemic stroke.

Author information

1
Department of Medical and Health Sciences, Linköping University, Linköping, Sweden lars-ake.levin@liu.se.
2
Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
3
Department of Clinical Sciences, Danderyd Hospital, Division of cardiovascular medicine, Karolinska Institutet, Stockholm, Sweden.

Abstract

AIMS:

The purpose of this study was to estimate the cost-effectiveness of two screening methods for detection of silent AF, intermittent electrocardiogram (ECG) recordings using a handheld recording device, at regular time intervals for 30 days, and short-term 24 h continuous Holter ECG, in comparison with a no-screening alternative in 75-year-old patients with a recent ischaemic stroke.

METHODS AND RESULTS:

The long-term (20-year) costs and effects of all alternatives were estimated with a decision analytic model combining the result of a clinical study and epidemiological data from Sweden. The structure of a cost-effectiveness analysis was used in this study. The short-term decision tree model analysed the screening procedure until the onset of anticoagulant treatment. The second part of the decision model followed a Markov design, simulating the patients' health states for 20 years. Continuous 24 h ECG recording was inferior to intermittent ECG in terms of cost-effectiveness, due to both lower sensitivity and higher costs. The base-case analysis compared intermittent ECG screening with no screening of patients with recent stroke. The implementation of the screening programme on 1000 patients resulted over a 20-year period in 11 avoided strokes and the gain of 29 life-years, or 23 quality-adjusted life years, and cost savings of €55 400.

CONCLUSION:

Screening of silent AF by intermittent ECG recordings in patients with a recent ischaemic stroke is a cost-effective use of health care resources saving costs and lives and improving the quality of life.

KEYWORDS:

Atrial fibrillation; Cost-effectiveness; Ischaemic stroke; QALY; Screening; Secondary prevention

PMID:
25349228
DOI:
10.1093/europace/euu213
[Indexed for MEDLINE]

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