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J Child Neurol. 2015 Jul;30(8):1024-8. doi: 10.1177/0883073814552191. Epub 2014 Oct 27.

Factors Associated With Increased In-Hospital Mortality Among Children With Intracerebral Hemorrhage.

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Department of Internal Medicine and Neurology, Ochsner Neuroscience Institute, Ochsner Clinic Foundation, New Orleans, LA, USA Zeenat Qureshi Stroke Institute, St Cloud, MN, USA
Zeenat Qureshi Stroke Institute, St Cloud, MN, USA.
Departments of Pediatrics and Neurology, Yale University School of Medicine, New Haven, CT, USA.
Department of Pediatrics, Division of Pediatric Neurology, Vanderbilt University School of Medicine, Nashville, TN, USA.


We assessed factors associated with mortality and potential targets for intervention in a large national sample of children with nontraumatic intracerebral hemorrhage. Using Healthcare Cost and Utilization Project Kids' Inpatient Database ICD-9-CM code 431 identified children aged 1 to 18 years with nontraumatic intracerebral hemorrhage in 2003, 2006 and 2009. Intracerebral hemorrhage was the primary diagnosis for 1172 children (ages 1-18 years) over the 3-year sample. Factors associated with mortality based on multivariable logistic regression included Hispanic ethnicity (odds ratio 1.9, 95% confidence interval 1.1-3.3), older age (11-18 vs 1-10 years, odds ratio 2.5, 95% confidence interval 1.3-5.0), coagulopathy (odds ratio 3.0, 95% confidence interval 1.6-6.0), and coma (odds ratio 9.0, 95% confidence interval 3.2-24.6). From 2003 to 2009, there was a non-significant decrease in mortality with a significant increase in length of stay from 9 to 11 days (P < .003). In children with intracerebral hemorrhage, coma and coagulopathy had the strongest association with mortality; coagulopathy is a potentially modifiable risk factor.


child; intracerebral hemorrhage; mortality

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