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Nucleic Acids Res. 2015 Jan;43(Database issue):D376-81. doi: 10.1093/nar/gku947. Epub 2014 Oct 27.

CATH: comprehensive structural and functional annotations for genome sequences.

Author information

1
Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK i.sillitoe@ucl.ac.uk.
2
Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
3
London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
4
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.

Abstract

The latest version of the CATH-Gene3D protein structure classification database (4.0, http://www.cathdb.info) provides annotations for over 235,000 protein domain structures and includes 25 million domain predictions. This article provides an update on the major developments in the 2 years since the last publication in this journal including: significant improvements to the predictive power of our functional families (FunFams); the release of our 'current' putative domain assignments (CATH-B); a new, strictly non-redundant data set of CATH domains suitable for homology benchmarking experiments (CATH-40) and a number of improvements to the web pages.

PMID:
25348408
PMCID:
PMC4384018
DOI:
10.1093/nar/gku947
[Indexed for MEDLINE]
Free PMC Article

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