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Expert Rev Proteomics. 2014 Dec;11(6):649-51. doi: 10.1586/14789450.2014.976559. Epub 2014 Oct 28.

Deep and quantitative top-down proteomics in clinical and translational research.

Author information

1
Northwestern University, 2145 N. Sheridan Rd, Evanston, IL, 60208, USA.

Abstract

It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics.

KEYWORDS:

clinical; proteomics; quantitative; top-down; translational

PMID:
25347991
PMCID:
PMC4295490
DOI:
10.1586/14789450.2014.976559
[Indexed for MEDLINE]
Free PMC Article

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