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Int J Mol Sci. 2014 Oct 24;15(11):19406-16. doi: 10.3390/ijms151119406.

Association study identifying a new susceptibility gene (AUTS2) for schizophrenia.

Author information

1
College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. zhangbao_814@mail.xjtu.edu.cn.
2
College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. yueyuehong921@stu.xjtu.edu.cn.
3
College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. weisg@mail.xjtu.edu.cn.
4
College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. zhanghb@mail.xjtu.edu.cn.
5
College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. fdk.1991.02.07@stu.xjtu.edu.cn.
6
College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. zufeifeng@mail.xjtu.edu.cn.
7
College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. fanglingguan@mail.xjtu.edu.cn.
8
College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. zys3000@mail.xjtu.edu.cn.
9
College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. shbinlee@mail.xjtu.edu.cn.

Abstract

Schizophrenia (SCZ) is a severe and debilitating mental disorder, and the specific genetic factors that underlie the risk for SCZ remain elusive. The autism susceptibility candidate 2 (AUTS2) gene has been reported to be associated with autism, suicide, alcohol consumption, and heroin dependence. We hypothesized that AUTS2 might be associated with SCZ. In the present study, three polymorphisms (rs6943555, rs7459368, and rs9886351) in the AUTS2 gene were genotyped in 410 patients with SCZ and 435 controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and forced PCR-RFLP methods. We detected an association between SCZ and the rs6943555 genotype distribution (odds ratio (OR)=1.363, 95% confidence interval (CI): 0.848-2.191, p=0.001). The association remained significant after adjusting for gender, and a significant effect (p=0.001) was observed among the females. In the present study, rs6943555 was determined to be associated with female SCZ. Our results confirm previous reports which have suggested that rs6943555 might elucidate the pathogenesis of schizophrenia and play an important role in its etiology.

PMID:
25347278
PMCID:
PMC4264119
DOI:
10.3390/ijms151119406
[Indexed for MEDLINE]
Free PMC Article

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