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Perspect Biol Med. 2014 Winter;57(1):149-61. doi: 10.1353/pbm.2014.0006.

The discovery of de novo gene evolution.

Abstract

Genes can evolve via duplication and divergence mechanisms, but also de novo out of non-coding intergenic sequences. This latter mechanism has only recently become fully appreciated, while the former mechanism was an almost exclusive dogma for quite some time. This essay explores the history of this development: why a view developed, with the alternative hardly being explored. Because of the prevailing view, an important aspect of the nature of genes and their evolutionary origin escaped our attention. Evidence is now rapidly accumulating that de novo evolution isa very active mechanism for generating novelty in the genome, and this will require anew look at how genes arise and become functional.

PMID:
25345708
DOI:
10.1353/pbm.2014.0006
[Indexed for MEDLINE]

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