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[The biological evaluation of depression severity: a novel method for the determination of platelet serotonin concentration].

[Article in Russian]

Abstract

OBJECTIVE:

To develop a highly sensitive method for the determination of platelet-rich plasma serotonin concentration for every-day clinical practice.

MATERIAL AND METHODS:

The method was developed for determination of serotonin in plateled-rich plasma. Serotonin was determined using high performance liquid chromatography with fluorescent detection and hematologic analyzer.

RESULTS AND CONCLUSION:

In healthy people, concentrations of platelet serotonin were similar to those reported in literature: from 2.19 to 4.87 nmol/109 platelets. In patients with depression (n=30), platelet serotonin concentrations were lower (from 0.11 to 2.89 nmol/109 platelets) and correlated with the severity of depression. The method may be used in clinical purposes.

PMID:
25345631
[Indexed for MEDLINE]

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