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Nat Commun. 2014 Oct 27;5:5281. doi: 10.1038/ncomms6281.

On the unfounded enthusiasm for soft selective sweeps.

Author information

1] School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1007, Switzerland [2] Swiss Institute of Bioinformatics (SIB), Lausanne 1007, Switzerland.


Underlying any understanding of the mode, tempo and relative importance of the adaptive process in the evolution of natural populations is the notion of whether adaptation is mutation limited. Two very different population genetic models have recently been proposed in which the rate of adaptation is not strongly limited by the rate at which newly arising beneficial mutations enter the population. However, empirical and experimental evidence to date challenges the recent enthusiasm for invoking these models to explain observed patterns of variation in humans and Drosophila.

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