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Otolaryngol Head Neck Surg. 2015 Jan;152(1):42-7. doi: 10.1177/0194599814555836. Epub 2014 Oct 24.

Treatment of aspirin exacerbated respiratory disease with a low salicylate diet: a pilot crossover study.

Author information

1
Division of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Canada.
2
Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Canada.
3
Department of Otolaryngology-Head and Neck Surgery, Western University, London, Canada.
4
Division of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Canada smriti.nayan@medportal.ca.

Erratum in

Abstract

OBJECTIVE:

Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment of this condition is challenging and may include topical/systemic steroids, endoscopic sinus surgery, and/or aspirin desensitization.

STUDY DESIGN:

A prospective crossover pilot study (n = 10) was conducted in which patients were randomized into either of 2 groups with 6 weeks of regular diet (R) or 6 weeks of a low salicylate diet (LS).

SETTING:

The study was conducted in a tertiary otolaryngology clinic.

SUBJECTS:

Patients with AERD were enrolled in the study.

METHODS:

Subjective (Sino-nasal Outcome Test-22 [SNOT-22], Nasal Sinus Symptom Scale [NSSS], and the Asthma Control Questionnaire-7 [ACQ-7]) and objective outcome instruments (Peri-Operative Sinus Evaluation [POSE] and Lund-Kennedy Endoscopic Score [LKES]) were used to evaluate patients at baseline, 6 weeks (at crossover), and 12 weeks.

RESULTS:

Wilcoxon rank sum tests demonstrated that patients on the low salicylate diet had improved scores compared to their regular diet when evaluated by 4 of the 5 outcome measures (SNOT-22 pLS = 0.0059, NSSS pLS = 0.0195, LKES pLS = 0.0039, POSE pLS = 0.005).

CONCLUSION:

Results of the pilot study indicate that implementation of a low salicylate diet improves the nasal symptoms and nasal endoscopy findings of individuals with AERD. Further research is required to support these findings.

KEYWORDS:

aspirin exacerbated respiratory disease; asthma; low salicylate diet; nasal polyps; salicylates; sinusitis

PMID:
25344589
DOI:
10.1177/0194599814555836
[Indexed for MEDLINE]

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