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IEEE Trans Biomed Circuits Syst. 2015 Jun;9(3):377-86. doi: 10.1109/TBCAS.2014.2354054. Epub 2014 Oct 16.

A 290 mV Sub-V(T) ASIC for Real-Time Atrial Fibrillation Detection.


A real-time detector for episodes of atrial fibrillation is fabricated as an application specific integrated circuit (ASIC). The basis for detection is a set of three parameters for characterizing the RR interval series, i.e., turning point ratio, root mean square of successive differences, and Shannon entropy. The developed hardware architecture targets ultra-low voltage operation, suitable for implantable loop recorders with ultra-low energy requirements. Algorithmic and architectural optimizations are performed to minimize area and energy dissipation, with a total area footprint reduction of 44%. The design is fabricated in 65-nm CMOS low-leakage high-threshold technology. Measurements with aggressively scaled supply voltage (VDD) in the subthreshold (sub-VT) region show energy savings of up to 41 X when operating at 1 kHz with a VDD of 300 mV compared to a nominal VDD of 1.2 V.

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