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Neuropsychiatr Dis Treat. 2014 Oct 14;10:1961-4. doi: 10.2147/NDT.S69039. eCollection 2014.

Neuropsychiatric symptoms and celiac disease.

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Affective and Psychotic Disorders Department, Medical University of ŁódŸ, ŁódŸ, Poland.
Department of Geriatric Medicine Medical University of ŁódŸ, ŁódŸ, Poland.
Department of Adolescent Psychiatry, Medical University of ŁódŸ, ŁódŸ, Poland.



Neuropsychiatric symptoms may represent an atypical manifestation of celiac disease that occur before a gastroenterological diagnosis is made. Some studies suggest that a gluten-free diet is effective in treating the depression, anxiety, and neurological complications associated with celiac disease.


The article describes the case of a patient suffering from chronic, treatment-resistant symptoms of depression and anxiety. The diagnosis of celiac disease and introduction of an elimination diet caused a significant improvement in mental state and everyday functioning in the presenting patient.


The presence of persistent anxiety and depressive symptoms, with a poor reaction to pharmacological treatment, indicates a need to identify somatic reasons for the underlying condition. It is important to remember that celiac disease can occur at any age, not only in childhood. The presence of this somatic cause of persistent depressive and anxiety symptoms should be considered in the diagnostic process in adults.


anemia; anxiety; depression; gluten; neurological complications

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