Format

Send to

Choose Destination
J Am Med Inform Assoc. 2015 Jan;22(1):43-50. doi: 10.1136/amiajnl-2014-002977. Epub 2014 Oct 23.

Toward a science of learning systems: a research agenda for the high-functioning Learning Health System.

Author information

1
University of Michigan, Ann Arbor, Michigan, USA.
2
Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
3
Vanderbilt University, Nashville, Tennessee, USA.
4
National Library of Medicine, Bethesda, Maryland, USA.
5
George Washington University, Washington, District of Columbia, USA.
6
University of Illinois, Urbana-Champaign, Illinois, USA.
7
Stanford University, Stanford, California, USA.
8
University of Virginia, Charlottesville, Virginia, USA.

Abstract

OBJECTIVE:

The capability to share data, and harness its potential to generate knowledge rapidly and inform decisions, can have transformative effects that improve health. The infrastructure to achieve this goal at scale--marrying technology, process, and policy--is commonly referred to as the Learning Health System (LHS). Achieving an LHS raises numerous scientific challenges.

MATERIALS AND METHODS:

The National Science Foundation convened an invitational workshop to identify the fundamental scientific and engineering research challenges to achieving a national-scale LHS. The workshop was planned by a 12-member committee and ultimately engaged 45 prominent researchers spanning multiple disciplines over 2 days in Washington, DC on 11-12 April 2013.

RESULTS:

The workshop participants collectively identified 106 research questions organized around four system-level requirements that a high-functioning LHS must satisfy. The workshop participants also identified a new cross-disciplinary integrative science of cyber-social ecosystems that will be required to address these challenges.

CONCLUSIONS:

The intellectual merit and potential broad impacts of the innovations that will be driven by investments in an LHS are of great potential significance. The specific research questions that emerged from the workshop, alongside the potential for diverse communities to assemble to address them through a 'new science of learning systems', create an important agenda for informatics and related disciplines.

KEYWORDS:

learning health system; population health; research agenda; system science

PMID:
25342177
PMCID:
PMC4433378
DOI:
10.1136/amiajnl-2014-002977
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center