Format

Send to

Choose Destination
Cold Spring Harb Perspect Med. 2014 Oct 23;5(1):a018531. doi: 10.1101/cshperspect.a018531.

Toward a unified biosignature for tuberculosis.

Author information

1
Max Planck Institute for Infection Biology, Department of Immunology, 10117 Berlin, Germany.

Abstract

Accurate and rapid diagnosis of active tuberculosis (TB) disease is still hampered by inadequate tools. Although current assays relying on single-marker readouts mostly display inadequate sensitivity and/or specificity, host-related multimarker signatures are especially poorly developed. As a consequence, research programs have been initiated to search for combinations of markers-so-called biosignatures with superior performance. Many such investigations harness high-throughput platforms to analyze the host response during infection and disease. A major challenge for these activities is the analysis of vast amounts of data produced. Specialized bioinformatic tools are being applied to identify the most robust biosignatures for classification of exposed and diseased individuals and prognosis of risk of disease in endemic areas. Validation of the most promising biosignatures in ongoing multicohort studies will bring us a step closer to the identification of an accurate unified signature.

PMID:
25342061
PMCID:
PMC4292082
DOI:
10.1101/cshperspect.a018531
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center