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Curr Genet. 1989 Oct;16(4):303-5.

An ethidium bromide induced mutant of Neurospora crassa defective in mitochondrial DNA.

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Department of Biological Sciences, University of South Carolina, Columbia 29208.


Slow growing mutants of Neurospora crassa were obtained by ethidium bromide treatment of the wild type strain. A particular mutant ER-3 showed stopper phenotype accompanied by deficient cytochrome spectra. The mutant showed an altered restriction pattern of the mtDNA which indicated a deletion of 25,000 bp. The phenotype of the ethidium bromide induced mutant ER-3 seem to be related to the loss of several essential genes due to a deletion in its mtDNA.

[Indexed for MEDLINE]

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