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J Comput Assist Tomogr. 2015 Jan-Feb;39(1):64-9. doi: 10.1097/RCT.0000000000000164.

Comparison of quantitative and semiquantitative dynamic contrast-enhanced MRI with respect to their correlation to delayed gadolinium-enhanced MRI of the cartilage in patients with early rheumatoid arthritis.

Author information

1
From the Departments of *Diagnostic and Interventional Radiology, and †Rheumatology, University Dusseldorf, Medical Faculty, Dusseldorf, Germany.

Abstract

OBJECTIVE:

The objective of this study was to investigate the correlation between semiquantitative and quantitative dynamic contrast-enhanced (DCE) parameters with delayed gadolinium-enhanced magnetic resonance imaging (MRI) of the cartilage (dGEMRIC).

METHODS:

Fifteen patients with early rheumatoid arthritis (RA) from the ArthroMark cohort were investigated at a 3-T MRI scanner. The metacarpophalangeal (MCP) joint of the index finger was examined with DCE-MRI and dGEMRIC. Semiquantitative and quantitative DCE perfusion parameters were calculated. The RA MRI score of the second MCP joint and the joint space width were measured.

RESULTS:

Significant correlations were noted between both semiquantitative and quantitative DCE parameters and the RA MRI score of the second MCP joint. There was a significant negative correlation between DCE parameters and dGEMRIC. No association between joint space width and DCE parameters was observed.

CONCLUSIONS:

Semiquantitative and quantitative analyses of perfusion are applicable to show that cartilage damage correlates with the inflammation activity despite the absence of joint space narrowing.

PMID:
25340588
DOI:
10.1097/RCT.0000000000000164
[Indexed for MEDLINE]

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