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J Renal Inj Prev. 2013 Nov 30;3(1):31-4. doi: 10.12861/jrip.2014.10. eCollection 2014.

Efficacy of supplementary vitamin D on improvement of glycemic parameters in patients with type 2 diabetes mellitus; a randomized double blind clinical trial.

Author information

1
Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran.
2
Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
3
Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4
Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
5
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Abstract

INTRODUCTION:

Studies have revealed the association between vitamin D deficiency and changes in blood glucose and insulin levels as well as sensitivity of the target tissues to insulin.

OBJECTIVE:

In this study, we examined the effect of adding vitamin D (cholecalciferol ; 50,000 units) to therapeutic regimen of T2DM patients compared to placebo on regulating the blood glucose and glycemic parameters.

PATIENTS AND METHODS:

This study was a double blind clinical trial conducted on 60 type 2 diabetes mellitus (T2DM) patients. Exclusion criteria were taking calcium, vitamin D supplements or any drugs effecting calcium and vitamin D metabolism in the past 6 months. Serum 25-Hydroxy vitamin D [25(OH)D] level was measured with ELISA method. Patients were administered weekly vitamin D supplementation (50000 units) for 12 weeks.

RESULTS:

There was no significant relation between HbA1c and 25(OH)D level prior the study (p> 0.05). After intervention, 25(OH)D level in interventional group was significantly higher compared to that of control group. HbA1c in male interventional group was significantly less than that of control group (p= 0.0068).

CONCLUSION:

Weekly vitamin D supplementation had beneficial effect on glycemic parameters in male type 2 diabetic patients.

KEYWORDS:

HbA1c; Type 2 diabetes patients; Vitamin D

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