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J Renal Inj Prev. 2013 Nov 30;3(1):31-4. doi: 10.12861/jrip.2014.10. eCollection 2014.

Efficacy of supplementary vitamin D on improvement of glycemic parameters in patients with type 2 diabetes mellitus; a randomized double blind clinical trial.

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Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.



Studies have revealed the association between vitamin D deficiency and changes in blood glucose and insulin levels as well as sensitivity of the target tissues to insulin.


In this study, we examined the effect of adding vitamin D (cholecalciferol ; 50,000 units) to therapeutic regimen of T2DM patients compared to placebo on regulating the blood glucose and glycemic parameters.


This study was a double blind clinical trial conducted on 60 type 2 diabetes mellitus (T2DM) patients. Exclusion criteria were taking calcium, vitamin D supplements or any drugs effecting calcium and vitamin D metabolism in the past 6 months. Serum 25-Hydroxy vitamin D [25(OH)D] level was measured with ELISA method. Patients were administered weekly vitamin D supplementation (50000 units) for 12 weeks.


There was no significant relation between HbA1c and 25(OH)D level prior the study (p> 0.05). After intervention, 25(OH)D level in interventional group was significantly higher compared to that of control group. HbA1c in male interventional group was significantly less than that of control group (p= 0.0068).


Weekly vitamin D supplementation had beneficial effect on glycemic parameters in male type 2 diabetic patients.


HbA1c; Type 2 diabetes patients; Vitamin D

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