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J Renal Inj Prev. 2013 Jun 1;2(2):47-50. doi: 10.12861/jrip.2013.17. eCollection 2013.

Serum lipoprotein (a) and atherosclerotic changes in hemodialysis patients.

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Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.



Lipoprotein (a) [Lp(a)] is considered as a risk factor for coronary atherosclerotic disorder and an increase in plasma Lp(a) concentration is usually seen in patients with kidney failure.


We aimed in this study to evaluate the impact of plasma Lp(a) level on early changes of atherosclerotic vessels in stable hemodialysis (HD) patients.


In this clinical study 61 patients (50 non-diabetic (F=20 M=30) and 11 diabetic HD patients), receiving maintenance hemodialysis were included and serum Lp(a) was measured. B-mode ultrasonography of carotid intima-media thickness (cIMT) was also determined.


The mean ±SD of patients Lp(a) was 58.5±19 mg/dL. The mean ±SD of diabetic patients' Lp(a) was 62±12mg/dL and for nondiabetic ones was 57.7± 20mg/dL. In this study the thickening of Intima-media complex in diabetic group was more than non-diabetics, and no significant difference was found of Lp(a) between diabetic and non diabetic HD patients. There was a significant positive association between serum Lp(a) and cIMT.


Accelerated atherosclerosis seen in diabetic hemodialysis patients. Lp(a) might have an important role in progression of atherosclerosis to accelerate progressive atherosclerosis in these patients.


Atherosclerosis; Diabetes mellitus; Hemodialysis; Intima-media thickness

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