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Oncoimmunology. 2014 Feb 14;3:e28047. eCollection 2014.

The battle for the brain: Brain tumor-initiating cells vs. microglia/macrophages.

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Hotchkiss Brain Institute and Department of Clinical Neurosciences; University of Calgary; Calgary, Canada.


Brain tumor-initiating cells (BTICs) become less tumorigenic when co-cultured with microglia/macrophages (M/Ms) isolated from subjects not affected by glioma, but not when exposed to the M/Ms of glioma patients. Microglial cells and macrophages from glioma patients, however, can be reactivated by non-toxic doses of amphotericin B to curb the growth of BTICs in vitro and in vivo.


amphotericin; glioma stem cells; innate immunity; microglia; reactivation

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