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J Clin Microbiol. 2015 Jan;53(1):9-14. doi: 10.1128/JCM.02187-14. Epub 2014 Oct 22.

Nontoxigenic Vibrio cholerae non-O1/O139 isolate from a case of human gastroenteritis in the U.S. Gulf Coast.

Author information

1
Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA University of Maryland Institute for Advanced Computer Studies, University of Maryland, College Park, Maryland, USA CosmosID, Inc., College Park, Maryland, USA.
2
Keesler Air Force Base, Biloxi, Mississippi, USA.
3
Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA CosmosID, Inc., College Park, Maryland, USA.
4
Gulf Coast Research Laboratory, The University of Southern Mississippi, Ocean Springs, Mississippi, USA.
5
Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
6
Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA Institute for Applied Environmental Health, University of Maryland, College Park, Maryland, USA.
7
Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA University of Maryland Institute for Advanced Computer Studies, University of Maryland, College Park, Maryland, USA CosmosID, Inc., College Park, Maryland, USA Institute for Applied Environmental Health, University of Maryland, College Park, Maryland, USA Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
8
Gulf Coast Research Laboratory, The University of Southern Mississippi, Ocean Springs, Mississippi, USA jay.grimes@usm.edu.

Abstract

An occurrence of Vibrio cholerae non-O1/O139 gastroenteritis in the U.S. Gulf Coast is reported here. Genomic analysis revealed that the isolate lacked known virulence factors associated with the clinical outcome of a V. cholerae infection but did contain putative genomic islands and other accessory virulence factors. Many of these factors are widespread among environmental strains of V. cholerae, suggesting that there might be additional virulence factors in non-O1/O139 V. cholerae yet to be determined. Phylogenetic analysis revealed that the isolate belonged to a phyletic lineage of environmental V. cholerae isolates associated with sporadic cases of gastroenteritis in the Western Hemisphere, suggesting a need to monitor non-O1/O139 V. cholerae in the interest of public health.

PMID:
25339398
PMCID:
PMC4290964
DOI:
10.1128/JCM.02187-14
[Indexed for MEDLINE]
Free PMC Article

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