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J Invest Dermatol. 2015 Mar;135(3):673-678. doi: 10.1038/jid.2014.401. Epub 2014 Oct 23.

Innate lymphoid cells in the skin.

Author information

1
Division of Dermatology, Department of Medicine, Center for the Study of Itch, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address: bkim@dom.wustl.edu.

Abstract

Innate lymphoid cells (ILCs) are part of a heterogeneous family of innate immune cells with newly identified roles in mediating immunity, tissue homeostasis, and pathologic inflammation. Here, we review recent studies delineating the roles of ILCs in the pathogenesis of multiple inflammatory skin disorders and their unique effector functions. Finally, we address how these studies have informed our understanding of the regulation of ILCs and the therapeutic potential of targeting these cells in the context of skin inflammation.

PMID:
25339380
PMCID:
PMC4556524
DOI:
10.1038/jid.2014.401
[Indexed for MEDLINE]
Free PMC Article

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