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Brain. 2014 Dec;137(Pt 12):3122-8. doi: 10.1093/brain/awu290. Epub 2014 Oct 22.

Consistent abnormalities in metabolic network activity in idiopathic rapid eye movement sleep behaviour disorder.

Author information

1
1 PET Centre, Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
2
2 Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
3
3 Centre for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA.
4
4 National Reference Network for Narcolepsy, Sleep Unit, Department of Neurology, Hôpital Gui-de-Chauliac, CHU Montpellier, Inserm U1061, University of Montpellier 1, Montpellier, France.
5
3 Centre for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA zuoct_cn2000@126.com yma@nshs.edu.
6
1 PET Centre, Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China zuoct_cn2000@126.com yma@nshs.edu.

Abstract

Rapid eye movement sleep behaviour disorder has been evaluated using Parkinson's disease-related metabolic network. It is unknown whether this disorder is itself associated with a unique metabolic network. 18F-fluorodeoxyglucose positron emission tomography was performed in 21 patients (age 65.0±5.6 years) with idiopathic rapid eye movement sleep behaviour disorder and 21 age/gender-matched healthy control subjects (age 62.5±7.5 years) to identify a disease-related pattern and examine its evolution in 21 hemi-parkinsonian patients (age 62.6±5.0 years) and 16 moderate parkinsonian patients (age 56.9±12.2 years). We identified a rapid eye movement sleep behaviour disorder-related metabolic network characterized by increased activity in pons, thalamus, medial frontal and sensorimotor areas, hippocampus, supramarginal and inferior temporal gyri, and posterior cerebellum, with decreased activity in occipital and superior temporal regions. Compared to the healthy control subjects, network expressions were elevated (P<0.0001) in the patients with this disorder and in the parkinsonian cohorts but decreased with disease progression. Parkinson's disease-related network activity was also elevated (P<0.0001) in the patients with rapid eye movement sleep behaviour disorder but lower than in the hemi-parkinsonian cohort. Abnormal metabolic networks may provide markers of idiopathic rapid eye movement sleep behaviour disorder to identify those at higher risk to develop neurodegenerative parkinsonism.

KEYWORDS:

18F-fluorodeoxyglucose; Parkinson’s disease; network biomarkers; positron emission tomography; rapid eye movement sleep behaviour disorder

PMID:
25338949
PMCID:
PMC4240297
DOI:
10.1093/brain/awu290
[Indexed for MEDLINE]
Free PMC Article

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