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J Nat Prod. 2014 Nov 26;77(11):2454-8. doi: 10.1021/np500522z. Epub 2014 Oct 22.

Chlorinated polyketide obtained from a Daldinia sp. treated with the epigenetic modifier suberoylanilide hydroxamic acid.

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Institute for Natural Products Applications and Research Technologies, Natural Products Discovery Group, and ‡Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma , 101 Stephenson Parkway, Norman, Oklahoma 73019-5251, United States.


A new chlorinated pentacyclic polyketide, daldinone E (1), was purified from a Daldinia sp. fungal isolate treated with the epigenetic modifier suberoylanilide hydroxamic acid (SAHA). A biosynthetically related epoxide-containing daldinone analogue, 2, was also purified from the same fungus. The structures of both compounds were established by spectroscopic methods, and the absolute configurations were assigned by analysis of their NMR data (coupling constants and ROESY correlations) and DFT calculations of specific rotations and ECD spectra. During the course of these studies it was determined that metabolite 2 and the previously reported daldinone B shared the same spectroscopic data, leading to a revision of the reported structure. Both compounds 1 and 2 also exhibited DPPH radical scavenging activities with potency comparable to the positive control ascorbic acid.

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