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ACS Nano. 2014 Nov 25;8(11):11042-52. doi: 10.1021/nn503960h. Epub 2014 Oct 22.

Structure and biomedical applications of amyloid oligomer nanoparticles.

Author information

1
Institute for Pharmaceutical Biotechnology, Ulm University , 89081 Ulm, Germany.

Abstract

Amyloid oligomers are nonfibrillar polypeptide aggregates linked to diseases, such as Alzheimer's and Parkinson's. Here we show that these aggregates possess a compact, quasi-crystalline architecture that presents significant nanoscale regularity. The amyloid oligomers are dynamic assemblies and are able to release their individual subunits. The small oligomeric size and spheroid shape confer diffusible characteristics, electrophoretic mobility, and the ability to enter hydrated gel matrices or cells. We finally showed that the amyloid oligomers can be labeled with both fluorescence agents and iron oxide nanoparticles and can target macrophage cells. Oligomer amyloids may provide a new biological nanomaterial for improved targeting, drug release, and medical imaging.

KEYWORDS:

cell penetration; delivery systems; neurodegeneration; peptide assembly; protein misfolding

PMID:
25337989
DOI:
10.1021/nn503960h
[Indexed for MEDLINE]

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