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PLoS One. 2014 Oct 22;9(10):e110269. doi: 10.1371/journal.pone.0110269. eCollection 2014.

Cardiovascular risks associated with low dose ionizing particle radiation.

Author information

1
Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts, United States of America; Tufts University School of Medicine, Boston, Massachusetts, United States of America.
2
Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts, United States of America.
3
Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts, United States of America; Calhoun Cardiology Center, University of Connecticut Health Center, Farmington, Connecticut, United States of America.
4
Steward Carney Hospital, Dorchester, Massachusetts, United States of America.
5
Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America.
6
Tufts University School of Medicine, Boston, Massachusetts, United States of America; Steward Carney Hospital, Dorchester, Massachusetts, United States of America.
7
Biosciences Department, Brookhaven National Laboratory, Upton, New York, United States of America.
8
Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts, United States of America; Tufts University School of Medicine, Boston, Massachusetts, United States of America; Steward St. Elizabeth's Medical Center, Boston, Massachusetts, United States of America.
9
Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America.
10
Feinberg Cardiovascular Institute, Northwestern University, Chicago, Illinois, United States of America.
11
Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts, United States of America; Tufts University School of Medicine, Boston, Massachusetts, United States of America; Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America.

Abstract

Previous epidemiologic data demonstrate that cardiovascular (CV) morbidity and mortality may occur decades after ionizing radiation exposure. With increased use of proton and carbon ion radiotherapy and concerns about space radiation exposures to astronauts on future long-duration exploration-type missions, the long-term effects and risks of low-dose charged particle irradiation on the CV system must be better appreciated. Here we report on the long-term effects of whole-body proton ((1)H; 0.5 Gy, 1 GeV) and iron ion ((56)Fe; 0.15 Gy, 1GeV/nucleon) irradiation with and without an acute myocardial ischemia (AMI) event in mice. We show that cardiac function of proton-irradiated mice initially improves at 1 month but declines by 10 months post-irradiation. In AMI-induced mice, prior proton irradiation improved cardiac function restoration and enhanced cardiac remodeling. This was associated with increased pro-survival gene expression in cardiac tissues. In contrast, cardiac function was significantly declined in (56)Fe ion-irradiated mice at 1 and 3 months but recovered at 10 months. In addition, (56)Fe ion-irradiation led to poorer cardiac function and more adverse remodeling in AMI-induced mice, and was associated with decreased angiogenesis and pro-survival factors in cardiac tissues at any time point examined up to 10 months. This is the first study reporting CV effects following low dose proton and iron ion irradiation during normal aging and post-AMI. Understanding the biological effects of charged particle radiation qualities on the CV system is necessary both for the mitigation of space exploration CV risks and for understanding of long-term CV effects following charged particle radiotherapy.

PMID:
25337914
PMCID:
PMC4206415
DOI:
10.1371/journal.pone.0110269
[Indexed for MEDLINE]
Free PMC Article

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