Format

Send to

Choose Destination
Nano Lett. 2014 Nov 12;14(11):6449-55. doi: 10.1021/nl502994y. Epub 2014 Oct 21.

A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins.

Author information

1
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital and ‡Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School , Boston, Massachusetts 02115, United States.

Abstract

Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

KEYWORDS:

Nanoparticles; biologics; solvent-free; therapeutic proteins; thermosponge

PMID:
25333768
PMCID:
PMC4245989
DOI:
10.1021/nl502994y
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center