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Biosci Biotechnol Biochem. 2015;79(2):247-52. doi: 10.1080/09168451.2014.972324. Epub 2014 Oct 21.

Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells.

Author information

1
a Department of Cosmetic Science and Management, Mackay Medicine , Nursing and Management College , Taipei , Taiwan, ROC.

Abstract

Curcumin is the major component of the yellow extract derived from the rhizome of the Curcuma longa, which is also a main bioactive polyphenol and has been generally used as a spice, food additive, and herbal medicine. In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing ELN and FBN1 promoters' activities. With 2 μM curcumin treatment, the enhanced tropoelastin and fibrillin-1 protein amounts in Detroit 551 cells were approximately 134 and 130% of control, respectively. Therefore, our results demonstrated that curcumin may be used as a functional compound and applied to drugs, foods, and cosmetics in the future.

KEYWORDS:

curcumin; elastin; fibrillin-1; fibroblast cells; promoter activity

PMID:
25333322
DOI:
10.1080/09168451.2014.972324
[Indexed for MEDLINE]

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