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Ann Hepatol. 2014 Nov-Dec;13(6):746-52.

Hepatitis C virus infection in patients and family members attending two primary care clinics in Puebla, Mexico.

Author information

1
Coordinación Delegacional de Investigación en Salud, Instituto Mexicano del Seguro Social, Puebla, México.
2
Servicio de Gastroenterología, Hospital de Especialidades, Unidad Médica de Alta Especialidad, Centro Médico Nacional General de División Manuel Ávila Camacho, Instituto Mexicano del Seguro Social, Puebla, México.
3
Facultad de Medicina, Universidad Popular Autónoma del Estado de Puebla, Puebla, México.
4
Dirección, Unidad de Medicina Familiar Núm. 55, Instituto Mexicano del Seguro Social, Puebla, México.
5
Coordinación Clínica de Educación e Investigación, Unidad de Medicina Familiar Núm. 6, Instituto Mexicano del Seguro Social, Puebla, México.
6
División de Epidemiología, Hospital de Especialidades, Unidad Médica de Alta Especialidad, Centro Médico Nacional General de División Manuel Ávila Camacho, Instituto Mexicano del Seguro Social, Puebla, México.
7
Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Metepec, Puebla, México.

Abstract

BACKGROUND:

Approximately 180 million persons (~2.8%) globally are estimated to be infected by hepatitis C virus (HCV). HCV prevalence in Mexico has been estimated to be between 1.2 and 1.4%. The aim of present work was to determine the prevalence of HCV infection in patients and family members attending two primary care clinics in Puebla, Mexico.

MATERIAL AND METHODS:

Patients and their accompanying family members in two clinics were invited to participate in this study between May and September 2010.

RESULTS:

A total of 10,214 persons were included in the study; 120 (1.17%) persons were anti-HCV reactive. Of the reactive subjects, detection of viral RNA was determined in 114 subjects and 36 were positive (31%). The more frequent risk factors were having a family history of cirrhosis (33.1%) and having a blood transfusion prior to 1995 (29%). After a multiple logistic regression analysis only transfusion prior to 1995 resulted significant to HCV transmission (p = 0.004). The overall detected HCV genotypes were as follows: 1a (29%), 1b (48.5%), 2/2b (12.8%), and 3a (6.5%).

CONCLUSION:

The HCV prevalence in this population is in agreement with previous studies in other regions of Mexico.

PMID:
25332260
[Indexed for MEDLINE]
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