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Am J Trop Med Hyg. 2014 Dec;91(6):1116-24. doi: 10.4269/ajtmh.14-0112. Epub 2014 Oct 20.

Eco-epidemiology of Chagas disease in an endemic area of Colombia: risk factor estimation, Trypanosoma cruzi characterization and identification of blood-meal sources in bugs.

Author information

1
Grupo Biología y Control de Enfermedades Infecciosas - BCEI, Universidad de Antioquia UdeA, Medellín, Colombia.
2
Grupo Biología y Control de Enfermedades Infecciosas - BCEI, Universidad de Antioquia UdeA, Medellín, Colombia otriana@gmail.com.

Abstract

The Sierra Nevada de Santa Marta (SNSM) is a mountainous area in Colombia that is highly endemic to Chagas disease. We explored some eco-epidemiological attributes involved in the Chagas disease transmission scenario in three Indigenous communities. An epidemiological survey was done, where parasite infection in reservoirs and insects, Trypanosoma cruzi genotyping, identification of blood-meal sources in intradomiciliary insects using the high-resolution melting technique, and some risk factors were evaluated. The results suggest that several dwelling conditions such as thatched palm roofs and mud walls carried the highest risk of finding intradomiciliary Rhodnius prolixus, which 56.41% were infected with T. cruzi and fed with human blood. Moreover, T. cruzi Ia was the most frequent haplotype found in insects. These results indicate the existence of a domestic T. cruzi transmission cycle that does not overlap with the sylvatic cycle, and highlight the need for efficient entomological control focused to this area.

PMID:
25331808
PMCID:
PMC4257632
DOI:
10.4269/ajtmh.14-0112
[Indexed for MEDLINE]
Free PMC Article

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