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J Ovarian Res. 2014 Oct 21;7:98. doi: 10.1186/s13048-014-0098-y.

Melatonin: shedding light on infertility?--A review of the recent literature.

Author information

1
MIMR-PHI Institute of Medical Research, 246 Clayton Rd, Clayton, 3168, , Victoria, Australia. shavif@hotmail.com.
2
Monash University, Department of Obstetrics and Gynaecology, Level 5 Monash Medical Centre, 246 Clayton Rd, Clayton, 3168, , Victoria, Australia. shavif@hotmail.com.
3
MIMR-PHI Institute of Medical Research, 246 Clayton Rd, Clayton, 3168, , Victoria, Australia. luk.rombauts@monash.edu.au.
4
Monash IVF, 252 Clayton rd, Clayton, 3168, , Victoria, Australia. luk.rombauts@monash.edu.au.

Abstract

In recent years, the negative impact of oxidative stress on fertility has become widely recognised. Several studies have demonstrated its negative effect on the number and quality of retrieved oocytes and embryos following in-vitro fertilisation (IVF). Melatonin, a pineal hormone that regulates circadian rhythms, has also been shown to exhibit unique oxygen scavenging abilities. Some studies have suggested a role for melatonin in gamete biology. Clinical studies also suggest that melatonin supplementation in IVF may lead to better pregnancy rates. Here we present a critical review and summary of the current literature and provide suggestions for future well designed clinical trials.

PMID:
25330986
PMCID:
PMC4209073
DOI:
10.1186/s13048-014-0098-y
[Indexed for MEDLINE]
Free PMC Article

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