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J Matern Fetal Neonatal Med. 2015;28(17):2096-9. doi: 10.3109/14767058.2014.979147. Epub 2014 Nov 14.

Circulating type 1 vaccine-derived poliovirus may evolve under the pressure of adenosine deaminases acting on RNA.

Author information

1
a College of Veterinary Medicine, Research Center for Animal Disease Control Engineering Shandong Province , Shandong Agricultural University , Tai`an , China.

Abstract

Poliovirus, the causative agent of poliomyelitis, is a human enterovirus and member of the Picornaviridae family. An effective live-attenuated poliovirus vaccine strain (Sabin 1) has been developed and has protected humans from polio. However, a few cases of vaccine virulence reversion have been documented in several countries. For instance, circulating type 1 vaccine-derived poliovirus is a highly pathogenic poliovirus that evolved from an avirulent strain, but the mechanism by which vaccine strains undergo reversion remains unclear. In this study, vaccine strains exhibited A to G/U to C and G to A/C to U hypermutations in the reversed evolution of Sabin 1. Furthermore, the mutation ratios of U to C and C to U were higher than those of other mutation types. Dinucleotide editing context was then analyzed. Results showed that A to G and U to C mutations exhibited preferences similar to adenosine deaminases acting on RNA (ADAR). Hence, ADARs may participate in poliovirus vaccine evolution.

KEYWORDS:

ADARs; APOBECs; circulating type 1 vaccine; mutation; polio virus

PMID:
25330844
DOI:
10.3109/14767058.2014.979147
[Indexed for MEDLINE]

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