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PLoS One. 2014 Oct 20;9(10):e108359. doi: 10.1371/journal.pone.0108359. eCollection 2014.

Interaction between neuroanatomical and psychological changes after mindfulness-based training.

Author information

1
Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Neurological, Neurosurgical and Behavioral Sciences, University of Siena, Siena, Italy; Berenson-Allen Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
2
Department of Neurological, Neurosurgical and Behavioral Sciences, University of Siena, Siena, Italy.
3
Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
4
Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

Abstract

Several cross-sectional studies have documented neuroanatomical changes in individuals with a long history of meditation, while a few evidences are available about the interaction between neuroanatomical and psychological changes even during brief exposure to meditation. Here we analyzed several morphometric indexes at both cortical and subcortical brain level, as well as multiple psychological dimensions, before and after a brief -8 weeks- Mindfulness Based Stress Reduction (MBSR) training program, in a group of 23 meditation naïve-subjects compared to age-gender matched subjects. We found a significant cortical thickness increase in the right insula and the somatosensory cortex of MBSR trainees, coupled with a significant reduction of several psychological indices related to worry, state anxiety, depression and alexithymia. Most importantly, an interesting correlation between the increase in right insula thickness and the decrease in alexithymia levels during the MBSR training were observed. Moreover, a multivariate pattern classification approach allowed to identify a cluster of regions more responsive to MBSR training across subjects. Taken together, these findings documented the significant impact of a brief MBSR training on brain structures, as well as stressing the idea of MBSR as a valuable tool for alexithymia modulation, also originally providing a plausible neurobiological evidence of a major role of right insula into mediating the observed psychological changes.

PMID:
25330321
PMCID:
PMC4203679
DOI:
10.1371/journal.pone.0108359
[Indexed for MEDLINE]
Free PMC Article

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