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Antioxid Redox Signal. 2015 May 1;22(13):1146-61. doi: 10.1089/ars.2014.5989. Epub 2014 Dec 11.

The inflammasome in myocardial injury and cardiac remodeling.

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1
1 VCU Pauley Heart Center, Virginia Commonwealth University , Richmond, Virginia.

Abstract

SIGNIFICANCE:

An inflammatory response follows an injury of any nature, and while such a response is an attempt to promote healing, it may, itself, result in further injury.

RECENT ADVANCES:

The inflammasome is a macromolecular structure recently recognized as a central mediator in the acute inflammatory response. The inflammasome senses the injury and it amplifies the response by leading to the release of powerful pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18.

CRITICAL ISSUES:

The activation of the inflammasome in the heart during ischemic and nonischemic injury represents an exaggerated response to sterile injury and promotes adverse cardiac remodeling and failure.

FUTURE DIRECTIONS:

Pilot clinical trials have explored blockade of the inflammasome-derived IL-1β and have shown beneficial effects on cardiac function. Additional clinical studies testing this approach are warranted. Moreover, specific inflammasome inhibitors that are ready for clinical use are currently lacking.

PMID:
25330141
DOI:
10.1089/ars.2014.5989
[Indexed for MEDLINE]
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