Format

Send to

Choose Destination
Nat Rev Microbiol. 2014 Dec;12(12):833-40. doi: 10.1038/nrmicro3364. Epub 2014 Oct 20.

Asymptomatic malaria infections: detectability, transmissibility and public health relevance.

Author information

1
1] London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. [2] Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.
2
Imperial College, London, London SW7 2AZ, UK.
3
Swiss Tropical Institute, 4051 Basel, Switzerland.
4
London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.

Abstract

Most Plasmodium falciparum infections that are detected in community surveys are characterized by low-density parasitaemia and the absence of clinical symptoms. Molecular diagnostics have shown that this asymptomatic parasitic reservoir is more widespread than previously thought, even in low-endemic areas. In this Opinion article, we describe the detectability of asymptomatic malaria infections and the relevance of submicroscopic infections for parasite transmission to mosquitoes and for community interventions that aim at reducing transmission. We argue that wider deployment of molecular diagnostic tools is needed to provide adequate insight into the epidemiology of malaria and infection dynamics to aid elimination efforts.

PMID:
25329408
DOI:
10.1038/nrmicro3364
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center