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Future Med Chem. 2014;6(12):1413-22. doi: 10.4155/fmc.14.86.

The antioxidant paradox: what are antioxidants and how should they be used in a therapeutic context for cancer.

Author information

1
Department of Dermatology, Winship Cancer Institute, Atlanta, GA, USA.

Abstract

So-called antioxidants have yet to make a clinical impact on the treatment of human cancer. The reasons for this failure are several. First, many agents that are called antioxidants are truly antioxidants at a given dose, but this dose may not have been given in clinical trials. Second, many agents are not antioxidants at all. Third, not all tumors use reactive oxygen as a signaling mechanism. Finally, reactive oxygen inhibition is often insufficient to kill or regress a tumor cell by itself, but requires sequential introduction of a therapeutic agent for maximal effect. We hope to provide a framework for the logical use of these agents in cancer.

PMID:
25329197
PMCID:
PMC4412352
DOI:
10.4155/fmc.14.86
[Indexed for MEDLINE]
Free PMC Article

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