Format

Send to

Choose Destination
Adv Mater. 2014 Dec 3;26(45):7615-21. doi: 10.1002/adma.201401554. Epub 2014 Oct 18.

Integration of nanoassembly functions for an effective delivery cascade for cancer drugs.

Author information

1
Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China, 310027; Department of Chemical Engineering, University of Wyoming, Laramie, WY, USA, 82071.

Abstract

A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release.

KEYWORDS:

biomedical applications; dendrimers; drug delivery; lipids; nanomedicine; self-assembly

PMID:
25328159
DOI:
10.1002/adma.201401554
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center