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Nat Commun. 2014 Oct 20;5:5258. doi: 10.1038/ncomms6258.

Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications.

Author information

1
Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
2
Materials Science Program, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
3
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
4
Department of Electrical Engineering and Computer Science, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA.
5
Department of Biomedical Engineering, Mahidol University, Bangkok 73170, Thailand.
6
1] Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA [2] Materials Science Program, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
7
1] Materials Science Program, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA [2] Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Abstract

Neural micro-electrode arrays that are transparent over a broad wavelength spectrum from ultraviolet to infrared could allow for simultaneous electrophysiology and optical imaging, as well as optogenetic modulation of the underlying brain tissue. The long-term biocompatibility and reliability of neural micro-electrodes also require their mechanical flexibility and compliance with soft tissues. Here we present a graphene-based, carbon-layered electrode array (CLEAR) device, which can be implanted on the brain surface in rodents for high-resolution neurophysiological recording. We characterize optical transparency of the device at >90% transmission over the ultraviolet to infrared spectrum and demonstrate its utility through optical interface experiments that use this broad spectrum transparency. These include optogenetic activation of focal cortical areas directly beneath electrodes, in vivo imaging of the cortical vasculature via fluorescence microscopy and 3D optical coherence tomography. This study demonstrates an array of interfacing abilities of the CLEAR device and its utility for neural applications.

PMID:
25327513
PMCID:
PMC4218963
DOI:
10.1038/ncomms6258
[Indexed for MEDLINE]
Free PMC Article

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