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Chem Commun (Camb). 2014 Dec 11;50(95):14995-7. doi: 10.1039/c4cc07326f.

A disulfide polymerized protein crystal.

Author information

1
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 2, SE-171 77 Stockholm, Sweden.

Abstract

The vDED coiled coil domain from human BAP29 was crystallized in dimeric and tetrameric forms. For the dimer, a disulfide bond was unexpectedly found to bridge a crystal contact, resulting in complete cross-linking along the c-axis. This indicates that it is in principle possible to design spontaneously polymerizing protein crystals.

PMID:
25327138
DOI:
10.1039/c4cc07326f
[Indexed for MEDLINE]

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