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Semin Ophthalmol. 2014 Sep-Nov;29(5-6):429-33. doi: 10.3109/08820538.2014.959188.

Complications of intra-arterial chemotherapy for retinoblastoma.

Author information

1
Children's Hospital , Boston, Massachusetts , USA.

Abstract

INTRODUCTION:

The purpose of this paper is to perform a systematic review of the published literature on complications of intra-arterial chemothrapy (IAC) for the treatment of retinoblastoma.

MATERIALS AND METHODS:

A literature search was performed using the Pubmed database using the terms. Complications were divided into extraocular and intraocular.

RESULTS:

A total of 117 articles were found using this Pubmed search method; 35 articles were selected for review as they describe specifical complications of IAC for retinoblastoma. A variety of extraocular and intraocular complications were reported and discussed.

DISCUSSION:

IAC for the treatment of retinoblastoma is a technique that has been gaining popularity in recent years, but is not without complications. Continued research is warranted to further improve current techniques and delivery of chemotherapeutic agents into the eye.

KEYWORDS:

Chemosurgery; chemotherapy; intra-arterial; melphalan; retinoblastoma; topotecan

PMID:
25325870
DOI:
10.3109/08820538.2014.959188
[Indexed for MEDLINE]

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