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Front Cell Infect Microbiol. 2014 Sep 29;4:137. doi: 10.3389/fcimb.2014.00137. eCollection 2014.

Defining the metabolic requirements for the growth and colonization capacity of Campylobacter jejuni.

Author information

1
Hannover Medical School, Institute for Medical Microbiology and Hospital Epidemiology Hannover, Germany.

Abstract

During the last decade Campylobacter jejuni has been recognized as the leading cause of bacterial gastroenteritis worldwide. This facultative intracellular pathogen is a member of the Epsilonproteobacteria and requires microaerobic atmosphere and nutrient rich media for efficient proliferation in vitro. Its catabolic capacity is highly restricted in contrast to Salmonella Typhimurium and other enteropathogenic bacteria because several common pathways for carbohydrate utilization are either missing or incomplete. Despite these metabolic limitations, C. jejuni efficiently colonizes various animal hosts as a commensal intestinal inhabitant. Moreover, C. jejuni is tremendously successful in competing with the human intestinal microbiota; an infectious dose of few hundreds bacteria is sufficient to overcome the colonization resistance of humans and can lead to campylobacteriosis. Besides the importance and clear clinical manifestation of this disease, the pathogenesis mechanisms of C. jejuni infections are still poorly understood. In recent years comparative genome sequence, transcriptome and metabolome analyses as well as mutagenesis studies combined with animal infection models have provided a new understanding of how the specific metabolic capacity of C. jejuni drives its persistence in the intestinal habitat of various hosts. Furthermore, new insights into the metabolic requirements that support the intracellular survival of C. jejuni were obtained. Because C. jejuni harbors distinct properties in establishing an infection in comparison to pathogenic Enterobacteriaceae, it represents an excellent organism for elucidating new aspects of the dynamic interaction and metabolic cross talk between a bacterial pathogen, the microbiota and the host.

KEYWORDS:

Campylobacter jejuni; amino acid catabolism; colonization; intermediary metabolism; intracellular survival; peptide catabolism; respiration

PMID:
25325018
PMCID:
PMC4178425
DOI:
10.3389/fcimb.2014.00137
[Indexed for MEDLINE]
Free PMC Article

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