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Eksp Klin Farmakol. 2014;77(7):8-10.

[Effect of coenzyme Q10 on rat myocardiumin the acute stage of experimental infarction].

[Article in Russian]


The influence of coenzyme Q10 (CoQ10) on early ischemic deterioration was studied on Wistar rats with experimental myocardial infarction. CoQ10 (30 mg/kg) was injected intravenously 10 min after coronary artery occlusion, and morphometric analysis was performed for 72 h after the onset of ischemia. CoQ10-treated rats had restricted total myocardial damage (by 52%), including areas of necrosis (by 84%) and areas of cellular inflammatory infiltration (by 38%) as compared to saline-treated rats (p < 0.001).

[Indexed for MEDLINE]

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