Format

Send to

Choose Destination
J Agric Food Chem. 2014 Nov 5;62(44):10752-8. doi: 10.1021/jf504058f. Epub 2014 Oct 27.

Potent inhibitory effect of δ-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo.

Author information

1
Allan H. Conney Laboratory for Anticancer Research, Guangdong University of Technology , Guangzhou 510006, People's Republic of China.

Abstract

In the present study, the effects of δ-tocopherol (δ-T) on growth and apoptosis of human prostate cancer cells were determined and compared with that of α-tocopherol (α-T), a commonly used form of vitamin E. Treatment of human prostate cancer cells with δ-T resulted in strong growth inhibition and apoptosis stimulation, while the effects of α-T were modest. The strong effects of δ-T on the cells were associated with suppression of androgen receptor (AR) activity and decreased level of prostate specific antigen (PSA) that is a downstream target of the AR signaling. In the in vivo study, we found that δ-T had a more potent inhibitory effect on the formation and growth of prostate xenograft tumors than that of α-T. Moreover, δ-T inhibited proliferation and stimulated apoptosis in the tumors. The present study identified δ-T as a better form of vitamin E than α-T for future clinical studies of prostate cancer prevention.

KEYWORDS:

AR signaling; apoptosis; prostate cancer; tocopherol; vitamin E; xenograft tumor

PMID:
25322450
PMCID:
PMC4334301
DOI:
10.1021/jf504058f
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center