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Afr Health Sci. 2014 Jun;14(2):434-8. doi: 10.4314/ahs.v14i2.20.

Nodding syndrome in Tanzania may not be associated with circulating anti-NMDA-and anti-VGKC receptor antibodies or decreased pyridoxal phosphate serum levels-a pilot study.

Author information

1
Department of Neurology, Medical University Innsbruck, Austria.
2
Central Institute of Medical and Chemical Laboratory Diagnostics, Medical University Innsbruck, Austria.
3
Division of Neurology, Muhimbili Medical Centre, Dar es Salaam, Tanzania.
4
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
5
Department of Neurology, Technical University Munich, Germany.

Abstract

BACKGROUND:

Nodding syndrome (NS) is a seemingly progressive epilepsy disorder of unknown underlying cause. We investigated association of pyridoxal-phosphate serum levels and occurrence of anti-neuronal antibodies against N-methyl-D-aspartate (NMDA) receptor and voltage gated potassium channel (VGKC) complex in NS patients.

METHODS:

Sera of a Tanzanian cohort of epilepsy and NS patients and community controls were tested for the presence of anti-NMDA-receptor and anti-VGKC complex antibodies by indirect immunofluorescence assay. Furthermore pyridoxal-phosphate levels were measured.

RESULTS:

Auto-antibodies against NMDA receptor or VGKC (LG1 or Caspr2) complex were not detected in sera of patients suffering from NS (n=6), NS plus other seizure types (n=16), primary generalized epilepsy (n=1) and community controls without epilepsy (n=7). Median Pyridoxal-phosphate levels in patients with NS compared to patients with primary generalized seizures and community controls were not significantly different. However, these median pyridoxal-phosphate levels are significantly lower compared to the range considered normal in Europeans.

CONCLUSIONS:

In this pilot study NS was not associated with serum anti-NMDA receptor or anti-VGKC complex antibodies and no association to pyridoxal-phosphate serum levels was found.

KEYWORDS:

anti-neuronal antibodies; epilepsy; nodding syndrome; pyridoxal-phosphate

PMID:
25320594
PMCID:
PMC4196418
DOI:
10.4314/ahs.v14i2.20
[Indexed for MEDLINE]
Free PMC Article

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