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J Virol. 2015 Jan;89(1):857-62. doi: 10.1128/JVI.02328-14. Epub 2014 Oct 15.

Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.

Author information

1
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Program in Virology, Harvard University Graduate School of Arts and Sciences, Division of Medical Sciences, Boston, Massachusetts, USA.
2
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
3
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA The BioFrontiers Institute, University of Colorado, Boulder, Colorado, USA.
4
Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA.
5
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
6
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
7
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
8
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
9
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Program in Virology, Harvard University Graduate School of Arts and Sciences, Division of Medical Sciences, Boston, Massachusetts, USA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA james_decaprio@dfci.harvard.edu.

Abstract

Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.

PMID:
25320321
PMCID:
PMC4301141
DOI:
10.1128/JVI.02328-14
[Indexed for MEDLINE]
Free PMC Article

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