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Biochem Biophys Res Commun. 1989 Dec 15;165(2):872-9.

Distribution and molecular forms of brain natriuretic peptide in porcine heart and blood.

Author information

1
Department of Biochemistry, Miyazaki Medical College, Japan.

Abstract

Although brain natriuretic peptide (BNP) is a novel natriuretic peptide originally identified in porcine brain, recent investigation has verified the presence of BNP in porcine heart. In order to identify BNP as a circulating hormone, we analyzed the regional distribution and molecular form of immunoreactive (ir-) BNP in heart and blood. Tissue concentration of ir-BNP was high in atrium, but low in ventricle, in a manner similar to that of atrial natriuretic peptide (ANP). However, the concentration of ir-BNP in atrium was only about 1/50 that of ir-ANP. In plasma, ir-BNP was found at a concentration of 1-3 fmol/ml, which was about 1/20 that of ir-ANP. Both ir-BNP and ir-ANP were present as low molecular weight forms. Three forms of ir-BNP of about 3K daltons, including BNP-26, BNP-29 and BNP-32, are thought to circulate in blood.

PMID:
2532010
DOI:
10.1016/s0006-291x(89)80047-6
[Indexed for MEDLINE]

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